Soranib
General information☝
Soranib is a generic medication that interferes with the growth and spread of cancer cells in the body. Sorafenib stops or slows the growth of cancer cells (tumors). It also works by slowing the growth of new blood vessels within the tumor. Soranib may also be used to treat a certain type of thyroid cancer (differentiated thyroid carcinoma).
Directions👈
Read the Patient Information Leaflet provided by your pharmacist before you start using sorafenib. Take this medication by mouth on an empty stomach (at least 1 hour before or 2 hours after a meal) as directed by your doctor, usually twice a day. Do not chew or crush the tablets. Swallow tablets whole with a full glass of water.
Precautions👈
Soranib can cause heart problems. Stop taking this medicine and call your doctor at once if you have chest pain and severe dizziness, fainting, sweating, or feeling short of breath. Soranib can also cause severe bleeding. Call your doctor if you have blood in your urine or stools, abnormal vaginal bleeding, severe stomach pain, coughing up blood, or any bleeding that will not stop. Do not have immunizations/vaccinations without the consent of your doctor and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose. To lower the chance of getting cut, bruised or injured, use caution with sharp objects like safety razors and nail cutters, and avoid activities such as contact sports. Women who are pregnant must not take this medication as it can be absorbed through the skin and lungs and may harm an unborn baby.
Contraindications👆
Before taking sorafenib, tell your doctor or pharmacist if you are allergic to it. You should not use Soranib if you have squamous cell lung cancer and you are being treated with carboplatin (Paraplatin) and paclitaxel (Onxol, Taxol, Abraxane). Do not use Soranib if you have kidney or liver problems other than cancer; lung cancer; a bleeding or blood clotting disorder such as hemophilia; high blood pressure (hypertension), heart disease, slow heartbeats, congestive heart failure, chest pain; a personal or family history of Long QT syndrome; a history of stroke or heart attack.
Possible side effect☝
The most common side effects are acne, dry skin, nausea, diarrhea, patchy hair loss/thinning, loss of appetite, dry mouth, hoarseness, or tiredness may occur. Notify your doctor if these effects persist or worsen. Serious side aeffects are bone/muscle pain, depression, easy bruising or bleeding, headache, tongue/mouth sores or pain, numbness/tingling of the hands/feet, shortness of breath, swollen hands/ankles/feet, signs of liver problems such as stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin, dark urine. Check your blood pressure regularly as this medication may raise it. This medication can affect how your thyroid works. Tell your doctor right away if you have signs of an underactive thyroid such as weight gain, cold intolerance, slow heartbeat, constipation, or unusual tiredness or signs of an overactive thyroid such as mental/mood changes, heat intolerance, fast/pounding/irregular heartbeat or unusual weight loss. Contact your doctor right away if you notice skin problems (such as rash, blisters, redness, swelling, pain), especially on the palms of your hands or the soles of your feet.
Drug interactions👈
The medications that may interact with Soranib are dexamethasone, neomycin, St. John's wort, a blood thinner such as Warfarin, Coumadin, seizure medication such as carbamazepine, fosphenytoin, phenobarbital, phenytoin or tuberculosis medicine such as rifabutin, rifampin.
Missed dose👈
Take the missed dose as soon as you remember, but at least 2 hours since your last meal. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Overdose💀
Seek emergency medical help at once if someone has overdosed and has serious symptoms such as passing out or trouble breathing.
Storage💬
Store at room temperature away from moisture and heat.
Note💬
The information presented at the site has a general character. Note please this information cannot be used for self-treatment and self diagnosis. You should consult with your doctor or health care adviser regarding any specific instructions of your condition. The information is reliable, but we concede it could contain mistakes. We are not responsible for any direct, indirect, special or other damage caused by use of this information on the site and also for consequences of self-treatment.
Treatment Choices by Stage for Kidney Cancer
ReplyDeleteThe type of treatment(s) your doctor recommends will depend on the stage of the cancer and on your overall health. This section sums up the options usually considered for each stage of kidney cancer.
Stage I and II cancers are still contained within the kidney. Stage III cancers have either grown into nearby large veins or have spread to nearby lymph nodes. These cancers are usually removed with surgery when possible. There are two common approaches:
ReplyDeletePartial nephrectomy (removing part of the kidney). This is often the treatment of choice in tumors up to 7 cm (a little less than 3 inches) if it can be done.
Radical nephrectomy (removing the entire kidney).
The lymph nodes near the kidney may be removed as well, especially if they are enlarged.
Stage IV kidney cancer means the cancer has grown outside of the kidney or has spread to other parts of the body such as distant lymph nodes or other organs.
ReplyDeleteTreatment of stage IV kidney cancer depends on how extensive the cancer is and on the person’s general health. In some cases, surgery may still be a part of treatment.
In rare cases where the main tumor appears to be removable and the cancer has only spread to one other area (such as to one or a few spots in the lungs), surgery to remove both the kidney and the metastasis (the outside area of cancer spread) may be an option if a person is in good enough health. Otherwise, treatment with one of the targeted therapies is usually the first option.
If the main tumor is removable but the cancer has spread extensively elsewhere, removing the kidney may still be helpful. This would likely be followed by systemic therapy, which might consist of one of the targeted therapies or immunotherapy (interleukin-2). More often targeted therapy is used first. It’s not clear if any one of the targeted therapies or any particular sequence is better than another, although temsirolimus appears to be most helpful for people with kidney cancers that have a poorer prognosis (outlook).
For cancers that can’t be removed surgically (because of the extent of the tumor or the person’s health), first-line treatment is likely to be one of the targeted therapies or cytokine therapy.
Because advanced kidney cancer is very hard to cure, clinical trials of new combinations of targeted therapies, immunotherapy, or other new treatments are also options.
For some people, palliative treatments such as embolization or radiation therapy may be the best option. A special form of radiation therapy called stereotactic radiosurgery can be very effective in treating single brain metastases. Surgery or radiation therapy can also be used to help reduce pain or other symptoms of metastases in some other places, such as the bones. You can read more about palliative treatment for cancer in Palliative (Supportive) Care or in Advanced Cancer, Metastatic Cancer, and Bone Metastasis.
Having your pain controlled can help you maintain your quality of life. Medicines to relieve pain do not interfere with your other treatments, and controlling pain will often help you be more active and continue your daily activities.
Recurrent cancer
ReplyDeleteCancer is called recurrent when it come backs after treatment. Recurrence can be local (near the area of the initial tumor) or it may be in distant organs. Treatment of kidney cancer that comes back (recurs) after initial treatment depends on where it recurs and what treatments have been used, as well as a person’s health and wishes for further treatment.
Local recurrence
ReplyDeleteFor cancers that recur after initial surgery, further surgery might be an option. Otherwise, treatment with targeted therapies or immunotherapy will probably be recommended. Clinical trials of new treatments are an option as well.
Distant recurrence
ReplyDeleteKidney cancer that recurs in distant parts of the body is treated like a stage IV cancer. Your options depend on which, if any, drugs you received before the cancer came back and how long ago you received them, as well as on your health?.
For cancers that progress (continue to grow or spread) during treatment with targeted therapy or cytokine therapy, another type of targeted therapy or immunotherapy may be helpful. If these don’t work, chemotherapy may be tried, especially for people with non-clear cell types of renal cell cancer. Recurrent cancers can sometimes be hard to treat, so you might also want to ask your doctor about clinical trials of newer treatments.
For some people with recurrent kidney cancer, palliative treatments such as embolization or radiation therapy may be the best option. Controlling symptoms such as pain is an important part of treatment at any stage of the disease.
The treatment information given here is not official policy of the American Cancer Society and is not intended as medical advice to replace the expertise and judgment of your cancer care team. It is intended to help you and your family make informed decisions, together with your doctor. Your doctor may have reasons for suggesting a treatment plan different from these general treatment options. Don't hesitate to ask him or her questions about your treatment options
ReplyDeleteDepression affects almost 20 percent of young adults with autism, new research shows, a rate that's more than triple that seen in the general population.
ReplyDeleteAnd young adults with autism who were relatively high-functioning -- meaning they did not have intellectual disabilities -- were actually at higher risk of depression than people with more severe forms of autism, British researchers found.
In the study, this higher-functioning subgroup was more than four times as likely to suffer from depression, compared to people without autism.
People with autism without intellectual disabilities "may be particularly prone to depression because of greater awareness of their difficulties," the researchers theorized.
Dr. Tom Frieden, a former director of the Centers for Disease Control and Prevention, was arrested for inappropriately touching a woman, according to the New York City Police Department.
ReplyDeleteThe alleged incident happened on Oct. 20, 2017, inside Frieden's Brooklyn residence, where a 55-year-old female acquaintance said he groped her rear, the NYPD said.
Frieden was charged with one count each of forcible touching, sex abuse and harassment, according to police.
Chemotherapy isn't generally used for the most common type of kidney cancer. You might have it if you have transitional cell cancer of the kidney.
ReplyDeleteYour liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons. Primary liver cancer starts in the liver. Metastatic liver cancer starts somewhere else and spreads to your liver.
ReplyDeleteRisk factors for primary liver cancer include
Having hepatitis B or C
Heavy alcohol use
Having cirrhosis, or scarring of the liver
Having hemochromatosis, an iron storage disease
Obesity and diabetes
Your liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons. Primary liver cancer starts in the liver. Metastatic liver cancer starts somewhere else and spreads to your liver.
ReplyDeleteRisk factors for primary liver cancer include
Having hepatitis B or C
Heavy alcohol use
Having cirrhosis, or scarring of the liver
Having hemochromatosis, an iron storage disease
Obesity and diabetes
Symptoms can include a lump or pain on the right side of your abdomen and yellowing of the skin. However, you may not have symptoms until the cancer is advanced. This makes it harder to treat. Doctors use tests that examine the liver and the blood to diagnose liver cancer. Treatment options include surgery, radiation, chemotherapy, or liver transplantation.