* Generic Name: lamivudine, zidovudine
* Brand Name: Combivir
* What is lamivudine and zidovudine (Combivir)?
* What are the possible side effects of lamivudine and zidovudine
(Combivir)?
* What is the most important information I should know about
lamivudine and zidovudine (Combivir)?
* What should I discuss with my healthcare provider before taking
lamivudine and zidovudine (Combivir)?
* How should I take lamivudine and zidovudine (Combivir)?
* What happens if I miss a dose (Combivir)?
* What happens if I overdose (Combivir)?
* What should I avoid while taking lamivudine and zidovudine
(Combivir)?
* What other drugs will affect lamivudine and zidovudine
(Combivir)?
* Where can I get more information (Combivir)?
What is lamivudine and zidovudine (Combivir)?
Lamivudine and zidovudine are antiviral medications that prevent
human immunodeficiency virus (HIV) from multiplying in your
body.
Lamivudine and zidovudine is a combination medicine used to treat HIV,
which causes the acquired immunodeficiency syndrome (AIDS).
This medicine is not a cure for HIV or AIDS.
Lamivudine and zidovudine may also be used for purposes not listed in
this medication guide.
What are the possible side effects of lamivudine and zidovudine (Combivir)?
Get emergency medical help if you have signs of an allergic reaction:
hives; difficult breathing; swelling of your face, lips, tongue, or
throat.
Early symptoms of lactic acidosis may get worse over time and this
condition can be fatal. Get emergency medical help if you have even
mild symptoms: muscle pain or weakness, numb or cold feeling in
your arms and legs, trouble breathing, stomach pain, nausea with
vomiting, fast or uneven heart rate, dizziness, or feeling very
weak or tired.
Call your doctor at once if you have:
* low white blood cell counts--fever, swollen gums, painful mouth
sores, pain when swallowing, skin sores, cold or flu symptoms,
cough, trouble breathing;
* low red blood cells (anemia)--pale skin, feeling light-headed
or short of breath, rapid heart rate, trouble concentrating; or
* liver problems--nausea, upper stomach pain, itching, tired feeling,
loss of appetite, dark urine, clay-colored stools,
jaundice (yellowing of the skin or eyes).
Lamivudine and zidovudine may increase your risk of certain infections
or autoimmune disorders by changing the way your immune system
works. Symptoms may occur weeks or months after you start treatment
with lamivudine and zidovudine. Tell your doctor if you have:
* signs of a new infection--fever, night sweats, swollen glands,
mouth sores, diarrhea, stomach pain, weight loss;
* chest pain (especially when you breathe), dry cough, wheezing,
feeling short of breath;
* cold sores, sores on your genital or anal area;
* rapid heart rate, feeling anxious or irritable, weakness or prickly
feeling, problems with balance or eye movement;
* trouble speaking or swallowing, severe lower back pain, loss of
bladder or bowel control; or
* swelling in your neck or throat (enlarged thyroid), menstrual
changes, impotence, loss of interest in sex.
Common side effects may include:
* headache;
* nausea, diarrhea;
* tiredness, general ill feeling;
* cold symptoms such as stuffy nose, sneezing, sinus
pain, cough; or
* changes in the shape or location of body fat (especially in your
arms, legs, face, neck, breasts, and trunk).
This is not a complete list of side effects and others may occur. Call
your doctor for medical advice about side effects. You may report side
effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about lamivudine and
zidovudine (Combivir)?
Do not take this medicine if you have ever had an allergic reaction to
any medicine that contains lamivudine or zidovudine.
Zidovudine can weaken your immune system and cause signs of infection
(fever, mouth sores, skin sores, flu symptoms, pale skin). Your blood
will need to be tested often. Long-term use of zidovudine can cause
muscle weakness, or loss of muscle tissue similar to "wasting
syndrome" caused by HIV.
This medicine may cause a serious condition called lactic acidosis. Get
emergency medical help if you have even mild symptoms such as: muscle
pain or weakness, numb or cold feeling in your arms and legs, trouble
breathing, stomach pain, nausea with vomiting, fast or uneven heart
rate, dizziness, or feeling very weak or tired.
If you have hepatitis B you may develop liver symptoms after you stop
taking medicine that contains lamivudine. Your doctor may want to check
your liver function for several months after you stop using lamivudine
and zidovudine.
Combivir Patient Information including How Should I Take
HIV AIDS: Myths and Facts on Symptoms and Treatments
HIV AIDS Myths and Facts Slideshow Pictures
RxList
Take the HIV/AIDS Quiz
AIDS Retrospective:Pictorial Timeline of the HIV/AIDS Pandemic
AIDS Retrospective Slideshow Pictures
What should I discuss with my healthcare provider before taking lamivudine
and zidovudine (Combivir)?
Do not take this medicine if you have ever had an allergic reaction to
any medicine that contains lamivudine, zidovudine, or emtricitabine.
This includes Atripla, Combivir, Complera, Emtriva,
Epivir, Epzicom, Retrovir, Stribild, Trizivir, and
Truvada.
Some people develop a life-threatening condition called lactic acidosis
while taking lamivudine and zidovudine. You may be more likely to
develop lactic acidosis if you are overweight or have liver
disease, if you are a woman, or if you have taken HIV or AIDS
medications for a long time. Talk with your doctor about your
individual risk.
Lamivudine and zidovudine can also cause severe or fatal liver
problems. Tell your doctor if you have liver disease, especially
hepatitis B.
Do not take Combivir with any other medicine that contains lamivudine,
zidovudine, or emtricitabine. This includes Atripla, Combivir,
Complera, Emtriva, Epivir, Epzicom, Retrovir, Stribild, Trizivir, and
Truvada.
To make sure you can safely take lamivudine and zidovudine, tell your
doctor if you have any of these other conditions:
* kidney disease;
* pancreas disorder (especially in a child taking this medicine); or
* if you take ribavirin to treat hepatitis C.
It is not known whether this medicine will harm an unborn baby. Tell
your doctor if you are pregnant or plan to become pregnant. HIV can be
passed to your baby if you are not properly treated during pregnancy.
Take all of your HIV medicines as directed to control your infection.
If you are pregnant, your name may be listed on a pregnancy registry.
This is to track the outcome of the pregnancy and to evaluate any
effects of lamivudine and zidovudine on the baby.
Women with HIV or AIDS should not breast-feed a baby. Even if your baby
is born without HIV, the virus may be passed to the baby in your breast
milk.
Lamivudine and zidovudine should not be used to treat HIV in
adolescents weighing less than 66 pounds.
How should I take lamivudine and zidovudine (Combivir)?
Follow all directions on your prescription label. Do not take this
medicine in larger or smaller amounts or for longer than recommended.
Lamivudine and zidovudine can be taken with or without food.
HIV/AIDS is usually treated with a combination of drugs. Use all
medications as directed by your doctor. Read the medication guide or
patient instructions provided with each medication. Do not change your
doses or medication schedule without your doctor's advice. Every person
with HIV or AIDS should remain under the care of a doctor.
Lamivudine and zidovudine can lower blood cells that help your body
fight infections and help your blood to clot. This can make it easier
for you to bleed from an injury or get sick from being around others
who are ill. Your blood may need to be tested often.
If you have hepatitis B you may develop liver symptoms after you stop
taking medicine that contains lamivudine. Your doctor may want to check
your liver function for several months after you stop using lamivudine
and zidovudine.
Store at room temperature away from moisture and heat.
Combivir Patient Information including If I Miss a Dose
HIV AIDS: Myths and Facts on Symptoms and Treatments
HIV AIDS Myths and Facts Slideshow Pictures
RxList
Take the HIV/AIDS Quiz
AIDS Retrospective:Pictorial Timeline of the HIV/AIDS Pandemic
AIDS Retrospective Slideshow Pictures
What happens if I miss a dose (Combivir)?
Take the missed dose as soon as you remember. Skip the missed dose if
it is almost time for your next scheduled dose. Do not take extra
medicine to make up the missed dose.
What happens if I overdose (Combivir)?
Seek emergency medical attention or call the Poison Help line at
1-800-222-1222.
What should I avoid while taking lamivudine and zidovudine (Combivir)?
Avoid being near people who are sick or have infections. Tell your
doctor at once if you develop signs of infection. Avoid activities that
may increase your risk of bleeding or injury. Use extra care to prevent
bleeding while shaving or brushing your teeth.
Taking this medicine will not prevent you from passing HIV to other
people. Do not have unprotected sex or share razors or toothbrushes.
Talk with your doctor about safe ways to prevent HIV transmission
during sex. Sharing drug or medicine needles is never safe, even for a
healthy person.
What other drugs will affect lamivudine and zidovudine (Combivir)?
Tell your doctor about all your current medicines and any you start or
stop using, especially:
* doxorubicin;
* ganciclovir;
* interferon alfa (Alferon A, Infergen, Intron A,
Rebetron);
* ribavirin;
* stavudine; or
* zalcitabine.
This list is not complete. Other drugs may interact with lamivudine and
zidovudine, including prescription and over-the-counter medicines,
vitamins, and herbal products. Not all possible interactions are listed
in this medication guide.
Where can I get more information (Combivir)?
Your pharmacist can provide more information about lamivudine and
zidovudine.
__________________________________________________________________
Remember, keep this and all other medicines out of the reach of
children, never share your medicines with others, and use this
medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by
Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete,
but no guarantee is made to that effect. Drug information contained
herein may be time sensitive. Multum information has been compiled for
use by healthcare practitioners and consumers in the United States and
therefore Multum does not warrant that uses outside of the United
States are appropriate, unless specifically indicated otherwise.
Multum's drug information does not endorse drugs, diagnose patients or
recommend therapy. Multum's drug information is an informational
resource designed to assist licensed healthcare practitioners in caring
for their patients and/or to serve consumers viewing this service as a
supplement to, and not a substitute for, the expertise, skill,
knowledge and judgment of healthcare practitioners. The absence of a
warning for a given drug or drug combination in no way should be
construed to indicate that the drug or drug combination is safe,
effective or appropriate for any given patient. Multum does not assume
any responsibility for any aspect of healthcare administered with the
aid of information Multum provides. The information contained herein is
not intended to cover all possible uses, directions, precautions,
warnings, drug interactions, allergic reactions, or adverse effects. If
you have questions about the drugs you are taking, check with your
doctor, nurse or pharmacist.
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