* Generic Name: trazodone hydrochloride
* Brand Name: Desyrel
* What is trazodone (Desyrel, Desyrel Dividose, Oleptro)?
* What are the possible side effects of trazodone (Desyrel,
Desyrel Dividose, Oleptro)?
* What is the most important information I should know about
trazodone (Desyrel, Desyrel Dividose, Oleptro)?
* What should I discuss with my healthcare provider before taking
trazodone (Desyrel, Desyrel Dividose, Oleptro)?
* How should I take trazodone (Desyrel, Desyrel Dividose,
Oleptro)?
* What happens if I miss a dose (Desyrel, Desyrel Dividose,
Oleptro)?
* What happens if I overdose (Desyrel, Desyrel Dividose,
Oleptro)?
* What should I avoid while taking trazodone (Desyrel, Desyrel
Dividose, Oleptro)?
* What other drugs will affect trazodone (Desyrel, Desyrel
Dividose, Oleptro)?
* Where can I get more information (Desyrel, Desyrel Dividose,
Oleptro)?
What is trazodone (Desyrel, Desyrel Dividose, Oleptro)?
Trazodone is an antidepressant medicine. It affects chemicals
in the brain that may be unbalanced in people with depression.
Trazodone is used to treat major depressive disorder.
Trazodone may also be used for purposes not listed in this medication
guide.
What are the possible side effects of trazodone (Desyrel, Desyrel Dividose,
Oleptro)?
Stop taking trazodone and call your doctor at once if you have a
penis erection that is painful or lasts 6 hours or longer. This is
a medical emergency and could lead to a serious condition that must be
corrected with surgery.
Get emergency medical help if you have signs of an allergic reaction:
hives; difficulty breathing; swelling of your face, lips, tongue, or
throat.
Report any new or worsening symptoms to your doctor, such as: mood or
behavior changes, anxiety, panic attacks, trouble sleeping, or if
you feel impulsive, irritable, agitated, hostile, aggressive, restless,
hyperactive (mentally or physically), more depressed, or have thoughts
about suicide or hurting yourself.
Call your doctor at once if you have:
* blurred vision, tunnel vision, eye pain or swelling, or
seeing halos around lights;
* headache with chest pain and severe dizziness, fainting, fast
or pounding heartbeats;
* chest pain or pressure, tight feeling in your neck or jaw,
sweating, pain spreading to your arm or shoulder;
* high levels of serotonin in the body--agitation,
hallucinations, fever, fast heart rate, overactive reflexes,
nausea, vomiting, diarrhea, loss of coordination, fainting;
* low levels of sodium in the body--headache, confusion, slurred
speech, severe weakness, vomiting, loss of coordination,
feeling unsteady; or
* severe nervous system reaction--very stiff (rigid) muscles, high
fever, sweating, confusion, fast or uneven heartbeats, tremors,
feeling like you might pass out.
Common side effects may include:
* drowsiness, dizziness;
* vision changes;
* constipation; or
* dry mouth, altered sense of taste.
This is not a complete list of side effects and others may occur. Call
your doctor for medical advice about side effects. You may report side
effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about trazodone
(Desyrel, Desyrel Dividose, Oleptro)?
You should not use trazodone if you are allergic to it, or if you are
being treated with methylene blue injection.
Do not use trazodone if you have taken an MAO inhibitor in the past 14
days. A dangerous drug interaction could occur. MAO inhibitors include
isocarboxazid, linezolid, phenelzine, rasagiline, selegiline,
and tranylcypromine.
Some young people have thoughts about suicide when first taking an
antidepressant. Your doctor will need to check your progress at regular
visits while you are using trazodone. Your family or other caregivers
should also be alert to changes in your mood or symptoms.
Report any new or worsening symptoms to your doctor, such as: mood or
behavior changes, anxiety, panic attacks, trouble sleeping, or if you
feel impulsive, irritable, agitated, hostile, aggressive, restless,
hyperactive (mentally or physically), more depressed, or have thoughts
about suicide or hurting yourself.
Do not give this medicine to anyone younger than 18 years old without
the advice of a doctor. Trazodone is not approved for use in children.
Desyrel Patient Information including How Should I Take
Depression Overview:What is Depression?
Understanding Depression Slideshow
RxList
Take the Depression Quiz
Depression:Tips for Exercise Diet and Stress Reduction
Depression Tips Slideshow Pictures
What should I discuss with my healthcare provider before taking trazodone
(Desyrel, Desyrel Dividose, Oleptro)?
You should not use trazodone if you are allergic to it, or if you are
being treated with methylene blue injection.
Do not use trazodone if you have taken an MAO inhibitor in the past 14
days. A dangerous drug interaction could occur. MAO inhibitors include
isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and
tranylcypromine. After you stop taking trazodone, you must wait at
least 14 days before you start taking an MAOI.
To make sure trazodone is safe for you, tell your doctor if you have:
* liver or kidney disease;
* heart disease;
* a bleeding or blood clotting disorder;
* seizures or epilepsy;
* narrow-angle glaucoma;
* bipolar disorder (manic depression);
* a history of Long QT syndrome;
* a history of drug abuse or suicidal thoughts; or
* if you have recently had a heart attack.
Some young people have thoughts about suicide when first taking an
antidepressant. Your doctor will need to check your progress at regular
visits while you are using trazodone. Your family or other caregivers
should also be alert to changes in your mood or symptoms.
Taking an SSRI antidepressant during pregnancy may cause serious
lung problems or other complications in the baby. However, you may have
a relapse of depression if you stop taking your antidepressant. Tell
your doctor right away if you become pregnant while taking trazodone.
Do not start or stop taking this medicine during pregnancy without your
doctor's advice.
It is not known whether trazodone passes into breast milk or if it
could harm a nursing baby. Tell your doctor if you are breast-feeding a
baby.
Do not give this medicine to anyone younger than 18 years old without
the advice of a doctor. Trazodone is not approved for use in children.
How should I take trazodone (Desyrel, Desyrel Dividose, Oleptro)?
Follow all directions on your prescription label. Your doctor may
occasionally change your dose to make sure you get the best results. Do
not take this medicine in larger or smaller amounts or for longer than
recommended.
The trazodone immediate-release tablet should be taken after a meal or
a snack.
Take Oleptro on an empty stomach at bedtime or late in the evening.
Do not crush, chew, or break an extended-release tablet. Swallow it
whole. You may break an Oleptro tablet in half along the score line
if needed.
It may take up to 2 weeks before your symptoms improve. Keep using the
medication as directed and tell your doctor if your symptoms do not
improve.
Do not stop using trazodone suddenly, or you could have unpleasant
withdrawal symptoms. Ask your doctor how to safely stop using
trazodone.
Store at room temperature away from moisture, heat, and light.
Desyrel Patient Information including If I Miss a Dose
Depression Overview:What is Depression?
Understanding Depression Slideshow
RxList
Take the Depression Quiz
Depression:Tips for Exercise Diet and Stress Reduction
Depression Tips Slideshow Pictures
What happens if I miss a dose (Desyrel, Desyrel Dividose, Oleptro)?
Take the missed dose as soon as you remember. Skip the missed dose if
it is almost time for your next scheduled dose. Do not take extra
medicine to make up the missed dose.
What happens if I overdose (Desyrel, Desyrel Dividose, Oleptro)?
Seek emergency medical attention or call the Poison Help line at
1-800-222-1222. An overdose of trazodone can be fatal when it is taken
with alcohol, barbiturates such as phenobarbital, or sedatives such as
diazepam (Valium).
Overdose symptoms may include extreme drowsiness, vomiting, penis
erection that is painful or prolonged, fast or pounding heartbeat,
seizure (black-out or convulsions), or breathing that slows or
stops.
What should I avoid while taking trazodone (Desyrel, Desyrel Dividose,
Oleptro)?
Do not drink alcohol. Trazodone can increase the effects of alcohol,
which could be dangerous.
Avoid getting up too fast from a sitting or lying position, or you may
feel dizzy. Get up slowly and steady yourself to prevent a fall.
Trazodone may impair your thinking or reactions. Be careful if you
drive or do anything that requires you to be alert.
Ask your doctor before taking a nonsteroidal anti-inflammatory drug
(NSAID) for pain, arthritis, fever, or swelling. This includes
aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib
(Celebrex), diclofenac, indomethacin, meloxicam, and
others. Using an NSAID with trazodone may cause you to bruise or bleed
easily.
What other drugs will affect trazodone (Desyrel, Desyrel Dividose, Oleptro)?
Taking this medicine with other drugs that make you sleepy can worsen
this effect. Ask your doctor before taking trazodone with a sleeping
pill, narcotic pain medicine, muscle relaxer, or medicine for
anxiety, depression, or seizures.
Many drugs can interact with trazodone. Not all possible interactions
are listed here. Tell your doctor about all your medications and any
you start or stop using during treatment with trazodone, especially:
* any other antidepressant;
* anagrelide;
* droperidol;
* methadone;
* ondansetron;
* an antibiotic--azithromycin, clarithromycin,
erythromycin, levofloxacin, moxifloxacin, pentamidine;
* cancer medicine--arsenic trioxide, vandetanib;
* anti-malaria medication--chloroquine, halofantrine;
* heart rhythm medicine--amiodarone, disopyramide, dofetilide,
dronedarone, flecainide, ibutilide, quinidine, sotalol; or
* medicine to treat a psychiatric disorder--chlorpromazine,
haloperidol, pimozide, thioridazine.
This list is not complete and many other drugs can interact with
trazodone. This includes prescription and over-the-counter medicines,
vitamins, and herbal products. Give a list of all your medicines to any
healthcare provider who treats you.
Where can I get more information (Desyrel, Desyrel Dividose, Oleptro)?
Your pharmacist can provide more information about trazodone.
__________________________________________________________________
Remember, keep this and all other medicines out of the reach of
children, never share your medicines with others, and use this
medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by
Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete,
but no guarantee is made to that effect. Drug information contained
herein may be time sensitive. Multum information has been compiled for
use by healthcare practitioners and consumers in the United States and
therefore Multum does not warrant that uses outside of the United
States are appropriate, unless specifically indicated otherwise.
Multum's drug information does not endorse drugs, diagnose patients or
recommend therapy. Multum's drug information is an informational
resource designed to assist licensed healthcare practitioners in caring
for their patients and/or to serve consumers viewing this service as a
supplement to, and not a substitute for, the expertise, skill,
knowledge and judgment of healthcare practitioners. The absence of a
warning for a given drug or drug combination in no way should be
construed to indicate that the drug or drug combination is safe,
effective or appropriate for any given patient. Multum does not assume
any responsibility for any aspect of healthcare administered with the
aid of information Multum provides. The information contained herein is
not intended to cover all possible uses, directions, precautions,
warnings, drug interactions, allergic reactions, or adverse effects. If
you have questions about the drugs you are taking, check with your
doctor, nurse or pharmacist.
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