* Generic Name: chlorambucil
* Brand Name: Leukeran
* What is chlorambucil (Leukeran)?
* What are the possible side effects of chlorambucil (Leukeran)?
* What is the most important information I should know about
chlorambucil (Leukeran)?
* What should I discuss with my healthcare provider before taking
chlorambucil (Leukeran)?
* How should I take chlorambucil (Leukeran)?
* What happens if I miss a dose (Leukeran)?
* What happens if I overdose (Leukeran)?
* What should I avoid while taking chlorambucil (Leukeran)?
* What other drugs will affect chlorambucil (Leukeran)?
* Where can I get more information (Leukeran)?
What is chlorambucil (Leukeran)?
Chlorambucil is a cancer medicine that interferes with the growth and
spread of cancer cells in the body.
Chlorambucil is used to treat several types of cancer, including
Hodgkin's disease and certain types of leukemia or
lymphoma.
Chlorambucil may also be used for purposes not listed in this
medication guide.
What are the possible side effects of chlorambucil (Leukeran)?
Get emergency medical help if you have signs of an allergic reaction:
hives; difficulty breathing; swelling of your face, lips, tongue, or
throat.
Call your doctor at once if you have:
* seizure (convulsions);
* an unusual mass or lump;
* severe vomiting or diarrhea;
* new or worsening cough;
* easy bruising, unusual bleeding (nose, mouth, vagina, or
rectum), purple or red pinpoint spots under your skin;
* liver problems--nausea, upper stomach pain, itching, tired feeling,
loss of appetite, dark urine, clay-colored stools,
jaundice (yellowing of the skin or eyes);
* low white blood cell counts--fever, swollen gums, painful mouth
sores, pain when swallowing, skin sores, cold or flu symptoms,
cough, trouble breathing; or
* severe skin reaction--fever, sore throat, swelling in your face
or tongue, burning in your eyes, skin pain, followed by a red or
purple skin rash that spreads (especially in the face or upper
body) and causes blistering and peeling.
Common side effects may include:
* bone marrow suppression (fever, bleeding, flu symptoms).
This is not a complete list of side effects and others may occur. Call
your doctor for medical advice about side effects. You may report side
effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about chlorambucil
(Leukeran)?
Chlorambucil can lower blood cells that help your body fight infections
and help your blood to clot. You may get an infection or bleed more
easily. Call your doctor if you have unusual bruising or bleeding, or
signs of infection (fever, chills, body aches).
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What should I discuss with my healthcare provider before taking chlorambucil
(Leukeran)?
You should not use chlorambucil if you are allergic to it, or if you
have received chlorambucil in the past without successful treatment of
your condition.
To make sure chlorambucil is safe for you, tell your doctor if you
have:
* kidney disease;
* liver disease;
* a history of seizures;
* a history of head injury or brain tumor; or
* if you have received radiation or chemotherapy within the
past 4 weeks.
Taking chlorambucil may increase your risk of developing other types of
cancer. Talk to your doctor about your specific risk.
Do not use chlorambucil if you are pregnant. It could harm the unborn
baby. Use effective birth control to prevent pregnancy during
treatment. Tell your doctor if you miss a menstrual period.
Chlorambucil may affect fertility (your ability to have children),
whether you are a man or a woman.
It is not known whether chlorambucil passes into breast milk or if it
could harm a nursing baby. You should not breast-feed while using this
medicine.
How should I take chlorambucil (Leukeran)?
You must remain under the care of a doctor while you are using
chlorambucil.
Chlorambucil is usually taken for 3 to 6 weeks. Follow all directions
on your prescription label. Your doctor may occasionally change your
dose to make sure you get the best results. Do not take this medicine
in larger or smaller amounts or for longer than recommended.
Chlorambucil can lower blood cells that help your body fight infections
and help your blood to clot. Your blood will need to be tested often.
Your cancer treatments may be delayed based on the results of these
tests.
Store chlorambucil tablets in the refrigerator, do not freeze.
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What happens if I miss a dose (Leukeran)?
Take the missed dose as soon as you remember. Skip the missed dose if
it is almost time for your next scheduled dose. Do not take extra
medicine to make up the missed dose.
What happens if I overdose (Leukeran)?
Seek emergency medical attention or call the Poison Help line at
1-800-222-1222.
What should I avoid while taking chlorambucil (Leukeran)?
This medicine can pass into body fluids (urine, feces, vomit).
Caregivers should wear rubber gloves while cleaning up a patient's body
fluids, handling contaminated trash or laundry or changing diapers.
Wash hands before and after removing gloves. Wash soiled clothing and
linens separately from other laundry.
Avoid being near people who are sick or have infections. Tell your
doctor at once if you develop signs of infection.
Avoid activities that may increase your risk of bleeding or injury. Use
extra care to prevent bleeding while shaving or brushing your teeth.
Do not receive a "live" vaccine while using chlorambucil. The vaccine
may not work as well during this time, and may not fully protect you
from disease. Live vaccines include measles, mumps,
rubella (MMR), rotavirus, typhoid, yellow fever,
varicella (chickenpox), zoster (shingles), and nasal
flu (influenza) vaccine.
What other drugs will affect chlorambucil (Leukeran)?
Other drugs may interact with chlorambucil, including prescription and
over-the-counter medicines, vitamins, and herbal products. Tell each of
your health care providers about all medicines you use now and any
medicine you start or stop using.
Where can I get more information (Leukeran)?
Your doctor or pharmacist can provide more information about
chlorambucil.
__________________________________________________________________
Remember, keep this and all other medicines out of the reach of
children, never share your medicines with others, and use this
medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by
Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete,
but no guarantee is made to that effect. Drug information contained
herein may be time sensitive. Multum information has been compiled for
use by healthcare practitioners and consumers in the United States and
therefore Multum does not warrant that uses outside of the United
States are appropriate, unless specifically indicated otherwise.
Multum's drug information does not endorse drugs, diagnose patients or
recommend therapy. Multum's drug information is an informational
resource designed to assist licensed healthcare practitioners in caring
for their patients and/or to serve consumers viewing this service as a
supplement to, and not a substitute for, the expertise, skill,
knowledge and judgment of healthcare practitioners. The absence of a
warning for a given drug or drug combination in no way should be
construed to indicate that the drug or drug combination is safe,
effective or appropriate for any given patient. Multum does not assume
any responsibility for any aspect of healthcare administered with the
aid of information Multum provides. The information contained herein is
not intended to cover all possible uses, directions, precautions,
warnings, drug interactions, allergic reactions, or adverse effects. If
you have questions about the drugs you are taking, check with your
doctor, nurse or pharmacist.
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