* Generic Name: allopurinol
* Brand Name: Zyloprim
* What is allopurinol (Lopurin, Zyloprim)?
* What are the possible side effects of allopurinol (Lopurin,
Zyloprim)?
* What is the most important information I should know about
allopurinol (Lopurin, Zyloprim)?
* What should I discuss with my healthcare provider before taking
allopurinol (Lopurin, Zyloprim)?
* How should I take allopurinol (Lopurin, Zyloprim)?
* What happens if I miss a dose (Lopurin, Zyloprim)?
* What happens if I overdose (Lopurin, Zyloprim)?
* What should I avoid while taking allopurinol (Lopurin,
Zyloprim)?
* What other drugs will affect allopurinol (Lopurin, Zyloprim)?
* Where can I get more information (Lopurin, Zyloprim)?
What is allopurinol (Lopurin, Zyloprim)?
Allopurinol reduces the production of uric acid in your body.
Uric acid buildup can lead to gout or kidney stones.
Allopurinol is used to treat gout or kidney stones, and to decrease
levels of uric acid in people who are receiving cancer treatment.
Allopurinol may also be used for purposes not listed in this medication
guide.
What are the possible side effects of allopurinol (Lopurin, Zyloprim)?
Get emergency medical help if you have any of these signs of an
allergic reaction: hives; difficult breathing; swelling of your face,
lips, tongue, or throat.
Stop using allopurinol and call your doctor at once if you have a
serious side effect such as:
* fever, sore throat, and headache with a severe blistering,
peeling, and red skin rash;
* the first sign of any skin rash, no matter how mild;
* pain or bleeding when you urinate;
* nausea, upper stomach pain, itching, loss of appetite, weight
loss, dark urine, clay-colored stools, jaundice (yellowing
of the skin or eyes);
* urinating less than usual or not at all;
* joint pain, flu symptoms;
* severe tingling, numbness, pain, muscle weakness; or
* easy bruising, unusual bleeding (nose, mouth, vagina, or
rectum), purple or red pinpoint spots under your skin.
Less serious side effects may include:
* vomiting, diarrhea;
* drowsiness, headache;
* changes in your sense of taste; or
* muscle pain.
This is not a complete list of side effects and others may occur. Call
your doctor for medical advice about side effects. You may report side
effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about allopurinol
(Lopurin, Zyloprim)?
Do not use this medication if you have ever had a serious allergic
reaction to allopurinol. Stop taking the medicine and call your doctor
at once if you have any signs of skin rash, no matter how mild.
Take each dose with a full glass of water. To reduce your risk of
kidney stones forming, drink 8 to 10 full glasses of fluid every day,
unless your doctor tells you otherwise.
Allopurinol can lower blood cells that help your body fight infections.
This can make it easier for you to bleed from an injury or get sick
from being around others who are ill. Your blood may need to be tested
often. Visit your doctor regularly.
Avoid drinking alcohol. It can make your condition worse.
Allopurinol may impair your thinking or reactions. Be careful if you
drive or do anything that requires you to be alert.
Zyloprim Patient Information including How Should I Take
RxList
Take the Gout Quiz
Gout: See & Learn About Gouty Arthritis Attacks
Gout Slideshow Pictures
Rheumatoid Arthritis Symptoms and Treatment
Rheumatoid Arthritis Slideshow
What should I discuss with my healthcare provider before taking allopurinol
(Lopurin, Zyloprim)?
You should not take allopurinol if you are allergic to it.
To make sure you can safely take allopurinol, tell your doctor if you
have any of these other conditions:
* kidney disease;
* liver disease;
* diabetes;
* congestive heart failure;
* high blood pressure; or
* if you are receiving any chemotherapy.
FDA pregnancy category C. It is not known whether allopurinol will harm
an unborn baby. Tell your doctor if you are pregnant or plan to become
pregnant while using this medication.
Allopurinol can pass into breast milk and may harm a nursing baby. Do
not use this medication without telling your doctor if you are
breast-feeding a baby.
How should I take allopurinol (Lopurin, Zyloprim)?
Take exactly as prescribed by your doctor. Do not take in larger or
smaller amounts or for longer than recommended. Follow the directions
on your prescription label.
Your doctor may occasionally change your dose to make sure you get the
best results.
Take each dose with a full glass of water. To reduce your risk of
kidney stones forming, drink 8 to 10 full glasses of fluid every day,
unless your doctor tells you otherwise.
You may have gout attacks more often when you first start taking
allopurinol. Your doctor may recommend other gout medication to take
with allopurinol. Keep using your medication as directed and tell your
doctor if your symptoms do not improve after a few months of treatment.
Allopurinol can lower blood cells that help your body fight infections.
This can make it easier for you to bleed from an injury or get sick
from being around others who are ill. Your blood may need to be tested
often. Visit your doctor regularly.
Store at room temperature away from moisture and heat.
Zyloprim Patient Information including If I Miss a Dose
RxList
Take the Gout Quiz
Gout: See & Learn About Gouty Arthritis Attacks
Gout Slideshow Pictures
Rheumatoid Arthritis Symptoms and Treatment
Rheumatoid Arthritis Slideshow
What happens if I miss a dose (Lopurin, Zyloprim)?
Take the missed dose as soon as you remember. Skip the missed dose if
it is almost time for your next scheduled dose. Do not take extra
medicine to make up the missed dose.
What happens if I overdose (Lopurin, Zyloprim)?
Seek emergency medical attention or call the Poison Help line at
1-800-222-1222.
What should I avoid while taking allopurinol (Lopurin, Zyloprim)?
Avoid being near people who are sick or have infections. Tell your
doctor at once if you develop signs of infection.
Allopurinol may impair your thinking or reactions. Be careful if you
drive or do anything that requires you to be alert.
Avoid drinking alcohol. It may worsen your condition.
Your doctor may recommend a special diet to help treat your
condition. Follow your diet and medication routines very closely.
What other drugs will affect allopurinol (Lopurin, Zyloprim)?
Tell your doctor about all other medicines you use, especially:
* azathioprine (Imuran);
* chlorpropamide (Diabinese);
* cyclosporine (Gengraf, Sandimmune, Neoral);
* mercaptopurine (Purinethol);
* an antibiotic such as ampicillin (Principen, Omnipen,
others) or amoxicillin (Amoxil, Augmentin, Trimox,
Wymox);
* a blood thinner such as dicoumarol or warfarin (Coumadin); or
* a diuretic (water pill).
This list is not complete and other drugs may interact with
allopurinol. Tell your doctor about all medications you use. This
includes prescription, over-the-counter, vitamin, and herbal products.
Do not start a new medication without telling your doctor.
Where can I get more information (Lopurin, Zyloprim)?
Your pharmacist can provide more information about allopurinol.
__________________________________________________________________
Remember, keep this and all other medicines out of the reach of
children, never share your medicines with others, and use this
medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by
Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete,
but no guarantee is made to that effect. Drug information contained
herein may be time sensitive. Multum information has been compiled for
use by healthcare practitioners and consumers in the United States and
therefore Multum does not warrant that uses outside of the United
States are appropriate, unless specifically indicated otherwise.
Multum's drug information does not endorse drugs, diagnose patients or
recommend therapy. Multum's drug information is an informational
resource designed to assist licensed healthcare practitioners in caring
for their patients and/or to serve consumers viewing this service as a
supplement to, and not a substitute for, the expertise, skill,
knowledge and judgment of healthcare practitioners. The absence of a
warning for a given drug or drug combination in no way should be
construed to indicate that the drug or drug combination is safe,
effective or appropriate for any given patient. Multum does not assume
any responsibility for any aspect of healthcare administered with the
aid of information Multum provides. The information contained herein is
not intended to cover all possible uses, directions, precautions,
warnings, drug interactions, allergic reactions, or adverse effects. If
you have questions about the drugs you are taking, check with your
doctor, nurse or pharmacist.
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