* Generic Name: glimepiride
* Brand Name: Amaryl Tablets
* What is glimepiride (Amaryl)?
* What are the possible side effects of glimepiride (Amaryl)?
* What is the most important information I should know about
glimepiride (Amaryl)?
* What should I discuss with my healthcare provider before taking
glimepiride (Amaryl)?
* How should I take glimepiride (Amaryl)?
* What happens if I miss a dose (Amaryl)?
* What happens if I overdose (Amaryl)?
* What should I avoid while taking glimepiride (Amaryl)?
* What other drugs will affect glimepiride (Amaryl)?
* Where can I get more information (Amaryl)?
What is glimepiride (Amaryl)?
Glimepiride is an oral diabetes medicine that helps control
blood sugar levels.
Glimepiride is used together with diet and exercise to treat
type 2 diabetes. Insulin or other diabetes medicines are
sometimes used in combination with glimepiride if needed.
Glimepiride may also be used for purposes not listed in this medication
guide.
What are the possible side effects of glimepiride (Amaryl)?
Get emergency medical help if you have signs of an allergic reaction:
hives; difficulty breathing; swelling of your face, lips, tongue, or
throat.
Call your doctor at once if you have:
* pale or yellowed skin, dark colored urine, fever, confusion or
weakness; or
* severe skin reaction--fever, sore throat, swelling in your face
or tongue, burning in your eyes, skin pain, followed by a red or
purple skin rash that spreads (especially in the face or upper
body) and causes blistering and peeling.
Common side effects may include:
* headache;
* dizziness, weakness;
* nausea; or
* flu symptoms.
This is not a complete list of side effects and others may occur. Call
your doctor for medical advice about side effects. You may report side
effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about glimepiride
(Amaryl)?
Do not use this medicine if you are in a state of diabetic
ketoacidosis (call your doctor for treatment with insulin).
Amaryl Patient Information including How Should I Take
Type 2 Diabetes Diagnosis, Treatment, Medication
Type 2 Diabetes: Learn the Warning Signs
Diabetes: Best and Worst Meals for Diabetes-Savvy Dining
Diabetes Friendly Dining
RxList
Type 2 Diabetes Quiz
What should I discuss with my healthcare provider before taking glimepiride
(Amaryl)?
You should not use glimepiride if you are allergic to it, or if you are
in a state of diabetic ketoacidosis (call your doctor for treatment
with insulin).
To make sure glimepiride is safe for you, tell your doctor if you have:
* heart disease;
* liver or kidney disease;
* an allergy to sulfa drugs;
* an enzyme deficiency called glucose-6-phosphate dehydrogenase
deficiency (G6PD);
* adrenal or pituitary gland problems; or
* if you are under-nourished.
It is not known whether glimepiride will harm an unborn baby. Similar
diabetes medications have caused severe hypoglycemia in newborn
babies whose mothers had used the medication near the time of delivery.
Tell your doctor if you are pregnant or plan to become pregnant while
using this medication.
It is not known whether glimepiride passes into breast milk or if it
could harm a nursing baby. Tell your doctor if you are breast-feeding a
baby.
How should I take glimepiride (Amaryl)?
Follow all directions on your prescription label. Your doctor may
occasionally change your dose to make sure you get the best results. Do
not take this medicine in larger or smaller amounts or for longer than
recommended.
Glimepiride is usually taken once a day with breakfast or the first
main meal of the day. Follow your doctor's instructions. Take
glimepiride with a full glass of water.
Your blood sugar will need to be checked often, and you may need other
blood tests at your doctor's office.
Low blood sugar (hypoglycemia) can happen to everyone who has diabetes.
Symptoms include headache, hunger, sweating, pale skin,
irritability, dizziness, feeling shaky, or trouble concentrating.
Always keep a source of sugar with you in case you have low blood
sugar. Sugar sources include fruit juice, hard candy, crackers,
raisins, and non-diet soda. Be sure your family and close friends know
how to help you in an emergency.
If you have severe hypoglycemia and cannot eat or drink, use a
glucagon injection. Your doctor can prescribe a glucagon emergency
injection kit and tell you how to use it.
Check your blood sugar carefully during times of stress, travel,
illness, surgery or medical emergency, vigorous exercise, or if you
drink alcohol or skip meals. These things can affect your glucose
levels and your dose needs may also change. Do not change your
medication dose or schedule without your doctor's advice.
Glimepiride is only part of a treatment program that may also include
diet, exercise, weight control, blood sugar testing, and special
medical care. Follow your doctor's instructions very closely.
Store at room temperature away from moisture and heat.
Amaryl Patient Information including If I Miss a Dose
Type 2 Diabetes Diagnosis, Treatment, Medication
Type 2 Diabetes: Learn the Warning Signs
Diabetes: Best and Worst Meals for Diabetes-Savvy Dining
Diabetes Friendly Dining
RxList
Type 2 Diabetes Quiz
What happens if I miss a dose (Amaryl)?
Take the missed dose as soon as you remember. Skip the missed dose if
it is almost time for your next scheduled dose. Do not take extra
medicine to make up the missed dose.
What happens if I overdose (Amaryl)?
Seek emergency medical attention or call the Poison Help line at
1-800-222-1222. A glimepiride overdose can cause life-threatening
hypoglycemia.
Symptoms of severe hypoglycemia include extreme weakness, confusion,
tremors, sweating, fast heart rate, trouble speaking, nausea,
vomiting, rapid breathing, fainting, and seizure
(convulsions).
What should I avoid while taking glimepiride (Amaryl)?
If you also take colesevelam, avoid taking it within 4 hours after you
take glimepiride.
Avoid drinking alcohol. It lowers blood sugar and may interfere with
your diabetes treatment.
Avoid exposure to sunlight or tanning beds. Glimepiride can make you
sunburn more easily. Wear protective clothing and use sunscreen
(SPF 30 or higher) when you are outdoors.
What other drugs will affect glimepiride (Amaryl)?
You may be more likely to have hypoglycemia (low blood sugar) if you
take glimepiride with other drugs that can lower blood sugar, such as:
* exenatide (Byetta);
* probenecid (Benemid);
* aspirin or other salicylates (including Pepto Bismol);
* a blood thinner (warfarin, Coumadin, Jantoven);
* sulfa drugs (Bactrim, SMZ-TMP, and others);
* a monoamine oxidase inhibitor (MAOI); or
* insulin or other oral diabetes medications.
This list is not complete, and many other medicines can increase or
decrease the effects of glimepiride on lowering your blood sugar. This
includes prescription and over-the-counter medicines, vitamins, and
herbal products. Tell your doctor about all medicines you use, and
those you start or stop using during your treatment with glimepiride.
Not all possible interactions are listed in this medication guide.
Where can I get more information (Amaryl)?
Your pharmacist can provide more information about glimepiride.
__________________________________________________________________
Remember, keep this and all other medicines out of the reach of
children, never share your medicines with others, and use this
medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by
Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete,
but no guarantee is made to that effect. Drug information contained
herein may be time sensitive. Multum information has been compiled for
use by healthcare practitioners and consumers in the United States and
therefore Multum does not warrant that uses outside of the United
States are appropriate, unless specifically indicated otherwise.
Multum's drug information does not endorse drugs, diagnose patients or
recommend therapy. Multum's drug information is an informational
resource designed to assist licensed healthcare practitioners in caring
for their patients and/or to serve consumers viewing this service as a
supplement to, and not a substitute for, the expertise, skill,
knowledge and judgment of healthcare practitioners. The absence of a
warning for a given drug or drug combination in no way should be
construed to indicate that the drug or drug combination is safe,
effective or appropriate for any given patient. Multum does not assume
any responsibility for any aspect of healthcare administered with the
aid of information Multum provides. The information contained herein is
not intended to cover all possible uses, directions, precautions,
warnings, drug interactions, allergic reactions, or adverse effects. If
you have questions about the drugs you are taking, check with your
doctor, nurse or pharmacist.
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