* Generic Name: prochlorperazine
* Brand Name: Compazine
* What is prochlorperazine (Compazine)?
* What are the possible side effects of prochlorperazine
(Compazine)?
* What is the most important information I should know about
prochlorperazine (Compazine)?
* What should I discuss with my healthcare provider before taking
prochlorperazine (Compazine)?
* How should I take prochlorperazine (Compazine)?
* What happens if I miss a dose (Compazine)?
* What happens if I overdose (Compazine)?
* What should I avoid while taking prochlorperazine (Compazine)?
* What other drugs will affect prochlorperazine (Compazine)?
* Where can I get more information (Compazine)?
What is prochlorperazine (Compazine)?
Prochlorperazine is an anti-psychotic medicine in a group of drugs
called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the
actions of chemicals in your brain.
Prochlorperazine oral (taken by mouth) is used to treat psychotic
disorders such as schizophrenia. It is also used to treat anxiety,
and to control severe nausea and vomiting.
Prochlorperazine may also be used for purposes not listed in this
medication guide.
What are the possible side effects of prochlorperazine (Compazine)?
Get emergency medical help if you have signs of an allergic reaction:
hives; difficult breathing; swelling of your face, lips, tongue, or
throat.
Stop taking prochlorperazine and call your doctor at once if you have
any of these signs of a serious movement disorder:
* tremors or shaking in your arms or legs;
* uncontrolled muscle movements in your face (chewing, lip smacking,
frowning, tongue movement, blinking or eye movement); or
* any new or unusual muscle movements you cannot control.
Also call your doctor at once if you have:
* a light-headed feeling, like you might pass out;
* little or no urinating;
* trouble swallowing, stiffness or muscle spasms in your neck;
* feeling restless, jittery, or agitated;
* jaundice (yellowing of the skin or eyes);
* fast or slow heart rate;
* low white blood cell counts--sudden weakness or ill feeling,
fever, chills, sore throat, swollen gums, mouth sores, pain
when swallowing, skin sores, cough, trouble breathing;
* lupus-like syndrome--joint pain or swelling with fever, swollen
glands, muscle aches, chest pain, vomiting, unusual thoughts or
behavior, and patchy skin color; or
* severe nervous system reaction--very stiff (rigid) muscles, high
fever, sweating, confusion, fast or uneven heartbeats, tremors,
feeling like you might pass out.
Side effects such as painful or difficult urination, constipation,
and confusion may be more likely in older adults.
Common side effects may include:
* dizziness, drowsiness;
* blurred vision;
* itching or rash;
* missed menstrual periods; or
* sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Call
your doctor for medical advice about side effects. You may report side
effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about prochlorperazine
(Compazine)?
You should not use prochlorperazine if you have recently used alcohol,
sedatives, tranquilizers, or narcotic medications.
Prochlorperazine is not approved for use by anyone younger than 2 years
old or weighing less than 20 pounds. Do not give this medicine to a
child before or after a surgery.
Prochlorperazine is not approved for use in psychotic conditions
related to dementia. Prochlorperazine may increase the risk of
death in older adults with dementia-related conditions.
Compazine Patient Information including How Should I Take
Schizophrenia: Types, Causes, Symptoms, and Treatment
Schizophrenia Slideshow Pictures
RxList
Take the Schizophrenia Quiz
What should I discuss with my healthcare provider before taking
prochlorperazine (Compazine)?
You should not use prochlorperazine if you are allergic to it, or if
you have recently used alcohol, sedatives, tranquilizers, or narcotic
medications.
Prochlorperazine is not approved for use in psychotic conditions
related to dementia. Prochlorperazine may increase the risk of death in
older adults with dementia-related conditions.
Prochlorperazine is not approved for use by anyone younger than 2 years
old or weighing less than 20 pounds. Talk with your doctor before
giving prochlorperazine to a child or teenager with a fever, flu
symptoms, vomiting, or diarrhea.
Do not give this medicine to a child before or after a surgery.
Long-term use of prochlorperazine can cause a serious movement disorder
that may not be reversible. The longer you take prochlorperazine, the
more likely you are to develop this movement disorder. The risk of this
side effect is higher in women and older adults.
To make sure prochlorperazine is safe for you, tell your doctor if you
have ever had:
* urination problems;
* a blockage in your intestines;
* glaucoma;
* heart disease;
* low blood pressure;
* breast cancer;
* liver disease;
* adrenal gland tumor (pheochromocytoma);
* seizures, or a history of brain tumor;
* Parkinson's disease; or
* a serious side effect while using prochlorperazine or another
phenothiazine.
Tell your doctor if you will be exposed to extreme heat or cold, or to
insecticide poisons while you are taking prochlorperazine.
It is not known whether this medicine will harm an unborn baby. Tell
your doctor if you are pregnant.
Taking antipsychotic medicine in the last 3 months of pregnancy may
cause problems in the newborn, such as withdrawal symptoms,
breathing problems, feeding problems, fussiness, tremors, and limp or
stiff muscles. However, you may have withdrawal symptoms or other
problems if you stop taking your medicine during pregnancy. If you
become pregnant, do not stop taking prochlorperazine without your
doctor's advice.
Prochlorperazine can pass into breast milk and may harm a nursing baby.
Tell your doctor if you are breast-feeding a baby.
How should I take prochlorperazine (Compazine)?
Follow all directions on your prescription label. Your doctor may
occasionally change your dose. Do not use this medicine in larger or
smaller amounts or for longer than recommended.
If you take prochlorperazine long-term, you may need frequent medical
tests.
Store at room temperature away from moisture, heat, and light.
Compazine Patient Information including If I Miss a Dose
Schizophrenia: Types, Causes, Symptoms, and Treatment
Schizophrenia Slideshow Pictures
RxList
Take the Schizophrenia Quiz
What happens if I miss a dose (Compazine)?
Take the missed dose as soon as you remember. Skip the missed dose if
it is almost time for your next scheduled dose. Do not take extra
medicine to make up the missed dose.
What happens if I overdose (Compazine)?
Seek emergency medical attention or call the Poison Help line at
1-800-222-1222.
Overdose can cause severe drowsiness, irregular heartbeats, agitation,
seizure, or fainting.
What should I avoid while taking prochlorperazine (Compazine)?
Drinking alcohol with this medicine can cause side effects.
This medication may cause drowsiness or blurred vision and may impair
your thinking or reactions. Be careful if you drive or do anything that
requires you to be alert and able to see clearly. Avoid getting up too
fast from a sitting or lying position, or you may feel dizzy. Get up
slowly and steady yourself to prevent a fall.
What other drugs will affect prochlorperazine (Compazine)?
Taking prochlorperazine with other drugs that make you sleepy or slow
your breathing can cause dangerous side effects or death. Ask your
doctor before taking a sleeping pill, opioid pain medicine,
prescription cough medicine, a muscle relaxer, or medicine for anxiety,
depression, or seizures.
Many drugs can interact with prochlorperazine. Not all possible
interactions are listed here. Tell your doctor about all your current
medicines and any you start or stop using, especially:
* lithium;
* propranolol;
* a diuretic or "water pill";
* a blood thinner (warfarin, Coumadin, Jantoven); or
* seizure medication.
This list is not complete and many other drugs can interact with
prochlorperazine. This includes prescription and over-the-counter
medicines, vitamins, and herbal products. Give a list of all your
medicines to any healthcare provider who treats you.
Where can I get more information (Compazine)?
Your pharmacist can provide more information about oral
prochlorperazine.
__________________________________________________________________
Remember, keep this and all other medicines out of the reach of
children, never share your medicines with others, and use this
medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by
Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete,
but no guarantee is made to that effect. Drug information contained
herein may be time sensitive. Multum information has been compiled for
use by healthcare practitioners and consumers in the United States and
therefore Multum does not warrant that uses outside of the United
States are appropriate, unless specifically indicated otherwise.
Multum's drug information does not endorse drugs, diagnose patients or
recommend therapy. Multum's drug information is an informational
resource designed to assist licensed healthcare practitioners in caring
for their patients and/or to serve consumers viewing this service as a
supplement to, and not a substitute for, the expertise, skill,
knowledge and judgment of healthcare practitioners. The absence of a
warning for a given drug or drug combination in no way should be
construed to indicate that the drug or drug combination is safe,
effective or appropriate for any given patient. Multum does not assume
any responsibility for any aspect of healthcare administered with the
aid of information Multum provides. The information contained herein is
not intended to cover all possible uses, directions, precautions,
warnings, drug interactions, allergic reactions, or adverse effects. If
you have questions about the drugs you are taking, check with your
doctor, nurse or pharmacist.
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