* Generic Name: pyrazinamide
* Brand Name: Pyrazinamide
* What is pyrazinamide?
* What are the possible side effects of pyrazinamide?
* What is the most important information I should know about
pyrazinamide?
* What should I discuss with my healthcare provider before taking
pyrazinamide?
* How should I take pyrazinamide?
* What happens if I miss a dose?
* What happens if I overdose?
* What should I avoid while taking pyrazinamide?
* What other drugs will affect pyrazinamide?
* Where can I get more information?
What is pyrazinamide?
Pyrazinamide is an antibiotic that fights bacteria.
Pyrazinamide is used to treat tuberculosis (TB) in adults and
children.
Pyrazinamide must be used with other TB medicines. Tuberculosis can
become resistant to treatment if pyrazinamide is used alone. Take all
your medicines as prescribed by your doctor.
Pyrazinamide may also be used for purposes not listed in this
medication guide.
What are the possible side effects of pyrazinamide?
Get emergency medical help if you have signs of an allergic reaction:
hives; difficult breathing; swelling of your face, lips, tongue, or
throat.
Call your doctor at once if you have:
* fever;
* joint pain or swelling;
* easy bruising or bleeding (nosebleeds, bleeding gums);
* gout flare-up symptoms--joint pain, stiffness, redness, or swelling
(especially at night); or
* liver problems--nausea, upper stomach pain, itching, tiredness,
loss of appetite, dark urine, clay-colored stools,
jaundice (yellowing of the skin or eyes).
Common side effects may include:
* joint or muscle pain;
* nausea, vomiting; or
* loss of appetite.
This is not a complete list of side effects and others may occur. Call
your doctor for medical advice about side effects. You may report side
effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about pyrazinamide?
You should not use pyrazinamide if you have active gout or severe
liver disease.
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What should I discuss with my healthcare provider before taking pyrazinamide?
You should not use pyrazinamide if you are allergic to it, or if you
have:
* active gout; or
* severe liver disease.
To make sure pyrazinamide is safe for you, tell your doctor if you
have:
* HIV or AIDS;
* gout;
* liver disease;
* diabetes; or
* if you drink large amounts of alcohol.
Your doctor will check your liver enzymes and uric acid levels before
you start treatment, to make sure you can safely take pyrazinamide.
It is not known whether pyrazinamide will harm an unborn baby. Tell
your doctor if you are pregnant or plan to become pregnant while using
this medicine.
Pyrazinamide can pass into breast milk and may harm a nursing baby.
Tell your doctor if you are breast-feeding a baby.
How should I take pyrazinamide?
Follow all directions on your prescription label. Your doctor may
occasionally change your dose to make sure you get the best results. Do
not use this medicine in larger or smaller amounts or for longer than
recommended.
Tuberculosis must be treated over a long period of time (up to 6 months
or longer).
Pyrazinamide is given in combination with other medications and should
not be used alone. You may need to take pyrazinamide for only the first
2 months of your full course of treatment.
Pyrazinamide is usually taken once per day. However, some people take
the medicine only 2 times per week.
Follow your doctor's dosing instructions very carefully.
Use this medicine for the full prescribed length of time. Your symptoms
may improve before the infection is completely cleared. Skipping doses
may also increase your risk of further infection that is resistant to
antibiotics. Pyrazinamide will not treat a viral infection such as
the flu or a common cold.
Tell your doctor if you have any changes in weight. Pyrazinamide doses
are based on weight (especially in children), and any changes may
affect the dose.
This medicine can cause unusual results with certain medical tests.
Tell any doctor who treats you that you are using pyrazinamide.
Store at room temperature away from moisture and heat.
Keep the bottle tightly closed when not in use.
Pyrazinamide Patient Information including If I Miss a Dose
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What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if
it is almost time for your next scheduled dose. Do not take extra
medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at
1-800-222-1222.
What should I avoid while taking pyrazinamide?
Follow your doctor's instructions about any restrictions on food,
beverages, or activity.
What other drugs will affect pyrazinamide?
Other drugs may interact with pyrazinamide, including prescription and
over-the-counter medicines, vitamins, and herbal products. Tell each of
your health care providers about all medicines you use now and any
medicine you start or stop using.
Where can I get more information?
Your pharmacist can provide more information about pyrazinamide.
__________________________________________________________________
Remember, keep this and all other medicines out of the reach of
children, never share your medicines with others, and use this
medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by
Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete,
but no guarantee is made to that effect. Drug information contained
herein may be time sensitive. Multum information has been compiled for
use by healthcare practitioners and consumers in the United States and
therefore Multum does not warrant that uses outside of the United
States are appropriate, unless specifically indicated otherwise.
Multum's drug information does not endorse drugs, diagnose patients or
recommend therapy. Multum's drug information is an informational
resource designed to assist licensed healthcare practitioners in caring
for their patients and/or to serve consumers viewing this service as a
supplement to, and not a substitute for, the expertise, skill,
knowledge and judgment of healthcare practitioners. The absence of a
warning for a given drug or drug combination in no way should be
construed to indicate that the drug or drug combination is safe,
effective or appropriate for any given patient. Multum does not assume
any responsibility for any aspect of healthcare administered with the
aid of information Multum provides. The information contained herein is
not intended to cover all possible uses, directions, precautions,
warnings, drug interactions, allergic reactions, or adverse effects. If
you have questions about the drugs you are taking, check with your
doctor, nurse or pharmacist.
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