* Generic Name: ranolazine
* Brand Name: Ranexa
* What is ranolazine (Ranexa)?
* What are the possible side effects of ranolazine (Ranexa)?
* What is the most important information I should know about
ranolazine (Ranexa)?
* What should I discuss with my health care provider before
taking ranolazine (Ranexa)?
* How should I take ranolazine (Ranexa)?
* What happens if I miss a dose (Ranexa)?
* What happens if I overdose (Ranexa)?
* What should I avoid while taking ranolazine (Ranexa)?
* What other drugs will affect ranolazine (Ranexa)?
* Where can I get more information (Ranexa)?
What is ranolazine (Ranexa)?
Ranolazine is an anti-anginal medication. It works by improving blood
flow to help the heart work more efficiently.
Ranolazine is used to treat chronic angina (chest pain). Ranolazine
is not for use during an acute (emergency) attack of angina.
Ranolazine may also be used for purposes not listed in this medication
guide.
What are the possible side effects of ranolazine (Ranexa)?
Get emergency medical help if you have signs of an allergic reaction:
hives; difficult breathing; swelling of your face, lips, tongue, or
throat.
Call your doctor at once if you have:
* a light-headed feeling, like you might pass out;
* headache with chest pain and severe dizziness, fast or pounding
heartbeats; or
* kidney problems--little or no urination, painful or difficult
urination, swelling in your feet or ankles, feeling tired or short
of breath.
Common side effects may include:
* nausea, constipation;
* headache; or
* dizziness.
This is not a complete list of side effects and others may occur. Call
your doctor for medical advice about side effects. You may report side
effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about ranolazine
(Ranexa)?
You should not take ranolazine if you have cirrhosis of the liver.
Serious drug interactions can occur when certain medicines are used
together with ranolazine. Tell each of your healthcare providers about
all medicines you use now, and any medicine you start or stop using.
Ranexa Patient Information including How Should I Take
Heart Disease:The No. 1 Killer in the U.S.
Heart Disease Slideshow Pictures
RxList
Medical Illustrations of the Heart Image Collection
RxList
Take the Heart Disease Quiz!
What should I discuss with my health care provider before taking ranolazine
(Ranexa)?
You should not take ranolazine if you are allergic to it, or if you
have cirrhosis of the liver.
Many other drugs can interact with ranolazine and should not be used at
the same time. Your doctor may need to change your treatment plan if
you use any of the following drugs:
* clarithromycin;
* nefazodone;
* St. John's wort;
* antifungal medicine--itraconazole, ketoconazole;
* HIV or AIDS medicine--indinavir, lopinavir/ritonavir,
nelfinavir, ritonavir, saquinavir;
* tuberculosis medicine--rifabutin, rifampin, rifapentine; or
* seizure medicine-carbamazepine, phenobarbital,
phenytoin.
To make sure ranolazine is safe for you, tell your doctor if you have:
* a heart rhythm disorder;
* liver disease;
* kidney disease; or
* a personal or family history of long QT syndrome.
It is not known whether this medicine will harm an unborn baby. Tell
your doctor if you are pregnant or plan to become pregnant.
It is not known whether ranolazine passes into breast milk or if it
could harm a nursing baby. Tell your doctor if you are breast-feeding a
baby.
How should I take ranolazine (Ranexa)?
Follow all directions on your prescription label. Your doctor may
occasionally change your dose to make sure you get the best results. Do
not use this medicine in larger or smaller amounts or for longer than
recommended.
Ranolazine may be taken with or without food.
Do not crush, chew, or break an extended-release tablet. Swallow it
whole.
Call your doctor if your symptoms do not improve, or if they get worse
while using ranolazine.
Chronic angina is often treated with a combination of drugs. Use all
medications as directed by your doctor. Read the medication guide or
patient instructions provided with each medication. Do not change your
doses or medication schedule without your doctor's advice.
Store at room temperature away from moisture and heat.
Ranexa Patient Information including If I Miss a Dose
Heart Disease:The No. 1 Killer in the U.S.
Heart Disease Slideshow Pictures
RxList
Medical Illustrations of the Heart Image Collection
RxList
Take the Heart Disease Quiz!
What happens if I miss a dose (Ranexa)?
Take the missed dose as soon as you remember. Skip the missed dose if
it is almost time for your next scheduled dose. Do not take extra
medicine to make up the missed dose.
What happens if I overdose (Ranexa)?
Seek emergency medical attention or call the Poison Help line at
1-800-222-1222.
Overdose can cause nausea, vomiting, numbness or tingling,
dizziness, double vision, confusion, or fainting.
What should I avoid while taking ranolazine (Ranexa)?
Ranolazine may impair your thinking or reactions. Be careful if you
drive or do anything that requires you to be alert.
Grapefruit and grapefruit juice may interact with ranolazine and
lead to unwanted side effects. Discuss the use of grapefruit products
with your doctor.
What other drugs will affect ranolazine (Ranexa)?
Many drugs can interact with ranolazine. Not all possible interactions
are listed here. Tell your doctor about all your medications and any
you start or stop using during treatment with ranolazine, especially:
* an antibiotic or antifungal medicine;
* any other medicine to treat heart disease;
* cholesterol-lowering medicine;
* diabetes medication;
* medicine to prevent organ transplant rejection;
* medicine to treat a mental illness; or
* medicine to treat or prevent nausea and vomiting caused by
chemotherapy or radiation.
This list is not complete and many other drugs can interact with
ranolazine. This includes prescription and over-the-counter medicines,
vitamins, and herbal products. Give a list of all your medicines to any
healthcare provider who treats you.
Where can I get more information (Ranexa)?
Your pharmacist can provide more information about ranolazine.
__________________________________________________________________
Remember, keep this and all other medicines out of the reach of
children, never share your medicines with others, and use this
medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by
Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete,
but no guarantee is made to that effect. Drug information contained
herein may be time sensitive. Multum information has been compiled for
use by healthcare practitioners and consumers in the United States and
therefore Multum does not warrant that uses outside of the United
States are appropriate, unless specifically indicated otherwise.
Multum's drug information does not endorse drugs, diagnose patients or
recommend therapy. Multum's drug information is an informational
resource designed to assist licensed healthcare practitioners in caring
for their patients and/or to serve consumers viewing this service as a
supplement to, and not a substitute for, the expertise, skill,
knowledge and judgment of healthcare practitioners. The absence of a
warning for a given drug or drug combination in no way should be
construed to indicate that the drug or drug combination is safe,
effective or appropriate for any given patient. Multum does not assume
any responsibility for any aspect of healthcare administered with the
aid of information Multum provides. The information contained herein is
not intended to cover all possible uses, directions, precautions,
warnings, drug interactions, allergic reactions, or adverse effects. If
you have questions about the drugs you are taking, check with your
doctor, nurse or pharmacist.
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